The (1–14) Fragment of Parathyroid Hormone (PTH) Activates Intact and Amino-Terminally Truncated PTH-1 Receptors
نویسندگان
چکیده
منابع مشابه
Origin of parathyroid hormone (PTH) fragments detected by intact-PTH assays.
BACKGROUND Intact parathyroid hormone (I-PTH) assays react with non-(1-84)PTH, large carboxyl-terminal (C) fragments with a partially preserved amino-terminal (N) structure. They account for up to 50% of I-PTH in renal failure and may be implicated in PTH resistance. We wanted to know if they were secreted by the parathyroid glands and generated by peripheral metabolism of PTH(1-84). METHODS ...
متن کاملRapid PTH assay by simple modification of Nichols intact PTH-Parathyroid Hormone Assay Kit.
In recent years, there has been an interest in producing a rapid, intraoperative assessment of parathyroid hormone (PTH) in serum to evaluate the efficacy of para-thyroid surgery [1-3]. Here, we report a simple modification of the intact PTH-parathyroid hormone overnight assay from Nichols Insutute Diagnostics (San Juan Capistrano, CA) that is usable by laboratories having Abbott (Abbott Park, ...
متن کاملInfluence of glomerular filtration rate on non-(1-84) parathyroid hormone (PTH) detected by intact PTH assays.
BACKGROUND Commercial intact parathyroid hormone (I-PTH) assays detect molecular form(s) of human PTH, non-(1-84) PTH, different from the 84-amino acid native molecule. These molecular form(s) accumulate in hemodialyzed patients. We investigated the importance of non-(1-84) PTH in the interpretation of the increased I-PTH in progressive renal failure. METHODS Five groups were studied: 26 heal...
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Humoral hypercalcemia of malignancy (HHM) results from the production of PTH-related protein (PTHrP) by human tumors. One previous study has reported the results of human (h) PTHrP(1-34) infusion into humans. In that report, hPTHrP(1-34) was found to be qualitatively similar to but 3- to 10-fold less potent than hPTH(1-34). Because hPTHrP(1-36) and not hPTH(1-34) is likely to be the actual amin...
متن کاملCritical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH.
Agonist-induced phosphorylation of the parathyroid hormone (PTH) receptor 1 (PTHR1) regulates receptor signaling in vitro, but the role of this phosphorylation in vivo is uncertain. We investigated this role by injecting "knock-in" mice expressing a phosphorylation-deficient (PD) PTHR1 with PTH ligands and assessing acute biologic responses. Following injection with PTH (1-34), or with a unique...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 1999
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend.13.5.0277